Statistical parametric mapping with 18F-dopa PET shows bilaterally reduced striatal and nigral dopaminergic function in early Parkinson's disease

Clinical and [18F] dopa PET findings in early Parkinson's disease.

Twenty seven patients with recent onset (mean symptom duration 22 (SD 14) months, Hoehn and Yahr score 1.8 (SD 0.7)) Parkinson's disease were studied with [18F]dopa PET. There was a correlation between putamen influx (Ki) and clinical rating, but not symptom duration. In 11 patients with hemi-Parkinson's disease of recent onset there were significant differences between normal (mean 0.0123 (SD ...

Frontal, midbrain and striatal dopaminergic function in early and advanced Parkinson's disease A 3D [(18)F]dopa-PET study.

We have studied focal changes in dopaminergic function throughout the brain volume in early and advanced Parkinson's disease by applying statistical parametric mapping (SPM) to 3D [(18)F]dopa-PET. Data from seven early hemi-Parkinson's disease and seven advanced bilateral Parkinson's disease patients were compared with that from 12 normal controls. Parametric images of [(18)F]dopa influx rate c...

[18F]fluorodopa PET shows striatal dopaminergic dysfunction in juvenile neuronal ceroid lipofuscinosis.

OBJECTIVES To investigate whether nigrostriatal dopaminergic hypofunction is related to the extrapyramidal symptoms in patients with juvenile neuronal ceroid lipofuscinosis (JNCL). METHODS Nine patients with JNCL and seven healthy controls were studied using [18F]fluorodopa PET. RESULTS In the patients with JNCL [18F]fluorodopa uptake (K[i][occ]) in the putamen was 60% of the control mean a...

Statistical Parametric Mapping with [F]FDOPA PET Demonstrating Difference in Dopaminergic Neuronal Function between Parkinson’s Disease and Olivopontine Cerebellar Atrophy

Received 8/31/2001; revised 10/20/2001; accepted 11/27/2001. For correspondence or reprints contact: Ren-Shyan Liu, M.D., Department of Nuclear Medicine, Taipei Veterans General Hospital, 201 Section 2, Shi-Pai Road, Taipei 112, Taiwan, R.O.C. Tel: (886)2-28715849, Fax: (886)2-28749431, E-mail: [email protected] Objective: Using statistical parametric mapping on [F]FDOPA PET image analysis to e...

18F-DOPA PET and PET/CT.